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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
26.97
Human Site:
T386
Identified Species:
45.64
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
T386
I
G
L
N
Q
P
S
T
P
T
H
A
A
G
V
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
T386
I
G
L
N
Q
P
S
T
P
T
H
A
A
G
V
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
T386
I
G
L
H
Q
P
S
T
P
T
H
A
A
G
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
T386
I
G
L
N
Q
P
S
T
P
T
H
A
A
S
I
Rat
Rattus norvegicus
Q01986
393
43447
T386
I
G
L
N
Q
P
S
T
P
T
H
A
A
S
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
T384
I
G
L
N
Q
P
S
T
P
T
H
A
A
G
V
Chicken
Gallus gallus
Q90891
398
44059
Frog
Xenopus laevis
Q05116
395
43724
T388
M
G
L
K
Q
P
S
T
P
T
H
A
A
G
V
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
S353
S
K
D
T
D
V
A
S
F
V
K
T
I
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
P389
M
D
L
P
P
S
T
P
K
R
N
T
S
P
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
E371
A
D
H
D
D
Q
G
E
F
A
V
F
V
K
G
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
N402
M
G
M
S
P
P
H
N
D
T
V
K
P
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
P661
N
G
L
S
K
N
V
P
A
L
H
M
G
G
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
93.3
N.A.
N.A.
86.6
86.6
N.A.
100
0
86.6
0
N.A.
6.6
N.A.
0
20
P-Site Similarity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
100
0
93.3
13.3
N.A.
33.3
N.A.
6.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
8
0
8
8
0
50
50
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
15
8
8
15
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
15
0
0
8
0
0
0
% F
% Gly:
0
65
0
0
0
0
8
0
0
0
0
0
8
43
15
% G
% His:
0
0
8
8
0
0
8
0
0
0
58
0
0
0
0
% H
% Ile:
43
0
0
0
0
0
0
0
0
0
0
0
8
0
15
% I
% Lys:
0
8
0
8
8
0
0
0
8
0
8
8
0
8
0
% K
% Leu:
0
0
65
0
0
0
0
0
0
8
0
0
0
15
8
% L
% Met:
22
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
8
0
0
36
0
8
0
8
0
0
8
0
0
0
8
% N
% Pro:
0
0
0
8
15
58
0
15
50
0
0
0
8
8
0
% P
% Gln:
0
0
0
0
50
8
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
8
0
0
15
0
8
50
8
0
0
0
0
8
15
0
% S
% Thr:
0
0
0
8
0
0
8
50
0
58
0
15
0
0
0
% T
% Val:
0
0
0
0
0
8
8
0
0
8
15
0
8
0
36
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _